Guy Vandenbranden is a celebrated Belgian Constructivist. His mature style was informed by the De Stijl and Op Art movements and their respective leading figures: Piet Mondrian and Victor Vasarély. Vandenbranden's work evolved from abstract paintings executed in mainly grey shades during the early 1950s to colourful works of Hard Edge Abstraction during the late 1950s. As of 1967, he further developed this style by spraying cellulose lacquer directly onto the panel.

Vandenbranden's wish to express his unique visual world in pure geometric lines, planes and colours led his paintings to become chromatically more complex with time. Dimension is achieved by cross-cutting the brightly coloured planes with broad black lines. In 1956, Vandenbranden joined the 'Art Abstrait' group, originally founded by Jo Delahaut, Pol Bury, Jean Milo and Georges Collignon. In 1960, Vandenbranden co-founded the 'New Flemish School' with Paul Van Hoeydonck, Jan Dries and Vic Gentils.

Guy Vandenbranden's work is included in the collections of the Royal Museum of Fine Arts, Antwerp; the Royal Museum of Fine Arts, Brussels; Musée des Beaux-Arts, Liège; Musée des Beaux-Arts, Verviers.